{"id":1560,"date":"2026-09-06T19:56:29","date_gmt":"2026-09-06T19:56:29","guid":{"rendered":"https:\/\/nex-chems.com\/?post_type=product&p=1560"},"modified":"2026-09-06T19:56:29","modified_gmt":"2026-09-06T19:56:29","slug":"sr-9011-powder","status":"publish","type":"product","link":"https:\/\/nex-chems.com\/fr\/product\/sr-9011-powder\/","title":{"rendered":"SR-9011 Powder"},"content":{"rendered":"

A. Introduction<\/h3>\n

SR-9011<\/b>\u00a0is a second-generation Rev-ErbA agonist that serves as a critical tool for research institutions investigating the molecular clock. By modulating the activity of Rev-ErbA receptors, SR-9011 allows researchers to study the intersection of circadian biology, lipid metabolism, and glucose homeostasis in controlled laboratory models.<\/p>\n

B. Scientific Overview<\/h3>\n

Chemically identified as 3-((((4-chlorophenyl)methyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylic acid ethyl ester ($C_{20}H_{24}ClN_{3}O_{4}S$), SR-9011 is a small molecule that enhances the constitutive repressor activity of Rev-ErbA. In\u00a0in-vitro<\/i>\u00a0assays, it is utilized to suppress the expression of core clock genes such as BMAL1 and CLOCK. Its study provides essential data on the pharmacological regulation of the REV-ERB\/BMAL1 transcriptional loop.<\/p>\n

C. Product Specifications<\/h3>\n
    \n
  • Form:<\/b>\u00a0Crystalline powder<\/li>\n
  • Chemical Class:<\/b>\u00a0Rev-ErbA Agonist<\/li>\n
  • Molecular Formula:<\/b>\u00a0$C_{20}H_{24}ClN_{3}O_{4}S$<\/li>\n
  • Molecular Weight:<\/b>\u00a0437.94 g\/mol<\/li>\n
  • Purity:<\/b>\u00a0\u226599% (HPLC\/NMR Verified)<\/li>\n
  • Solubility:<\/b>\u00a0Soluble in DMSO (up to 50 mg\/mL) and Ethanol<\/li>\n
  • Storage:<\/b>\u00a0Store in a cool, dry environment (15\u00b0C to 25\u00b0C) in an airtight container; protect from light and moisture.<\/li>\n<\/ul>\n

    D. Laboratory Use Context<\/h3>\n

    This pure powder format is provided exclusively for\u00a0in-vitro research<\/b>\u00a0and\u00a0analytical testing<\/b>. It is an ideal reagent for:<\/p>\n

      \n
    • Investigating Rev-ErbA-mediated gene transcription in cell cultures.<\/li>\n
    • Studying the molecular mechanisms of the circadian clock in metabolic tissues.<\/li>\n
    • Calibrating LC-MS and GC-MS equipment for metabolic modulator screening.<\/li>\n
    • In-vitro<\/i>\u00a0stability and toxicity profiling in synthetic biological matrices.<\/li>\n<\/ul>\n

      E. Quality Testing<\/h3>\n
        \n
      • HPLC Verification:<\/b>\u00a0Every batch is verified for chemical purity and the absence of related synthesis precursors.<\/li>\n
      • Structural Identity:<\/b>\u00a0Mass Spectrometry (MS) and Proton NMR ensure the correct identification of the pyrrolidine and thiophene structural components.<\/li>\n
      • Batch Consistency:<\/b>\u00a0Rigorous manufacturing standards ensure that every unit provides reproducible results for long-term longitudinal studies.<\/li>\n
      • COA:<\/b>\u00a0Detailed Certificates of Analysis are available for all institutional research requirements.<\/li>\n<\/ul>\n

        F. Shipping Handling<\/h3>\n

        Our SR-9011 powder is dispatched in professional, vacuum-sealed, and UV-protected packaging to maintain the stability of the compound during transit. We provide reliable, discreet worldwide shipping to research facilities and commercial laboratories, ensuring all necessary documentation is included for compliant logistics.<\/p>\n

        G. Compliance Disclaimer (CLEAR PROMINENT)<\/h3>\n

        FOR RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION.<\/b>\u00a0This product is a research chemical and is strictly for\u00a0in-vitro<\/i>\u00a0laboratory applications and analytical testing. It is not intended for diagnostic or therapeutic use in humans or animals. No instructions for administration or medical dosages are provided. The purchaser assumes all responsibility for compliance with local and international regulations regarding the acquisition and handling of this substance.<\/p><\/blockquote>","protected":false},"excerpt":{"rendered":"

        A. Introduction SR-9011\u00a0is a second-generation Rev-ErbA agonist that serves as a critical tool for research institutions investigating the molecular clock. 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