LGD-4033 Powder (Ligandrol)

A. Introduction

LGD-4033 (Ligandrol) is one of the most extensively documented compounds in the SARM category. Developed to address muscle wasting and osteoporosis, it is utilized by research institutions to study the selective activation of androgen receptors in bone and muscle tissues with significantly reduced impact on the prostate and sebaceous glands compared to traditional androgens.

B. Scientific Overview

Chemically identified as 4-((R)-2-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile (C14​H12​F6​N2​O), LGD-4033 is a pyrrolidine-based ligand. In research settings, it is utilized to study the molecular mechanisms of myogenic differentiation and the up-regulation of anabolic gene expression. Its high binding affinity (Ki​ of ~1 nM) makes it an essential reference standard for comparative pharmacological analysis.

C. Product Specifications

• Form: Crystalline powder
• Chemical Class: Pyrrolidine / SARM
• Molecular Formula: C14​H12​F6​N2​O
• Molecular Weight: 338.25 g/mol
• Purity: ≥99% (HPLC/NMR Verified)
• Solubility: Soluble in DMSO (up to 30 mg/mL) and Ethanol
• Storage: Store at room temperature (15°C to 25°C) in a dry, airtight container protected from light and moisture.

D. Laboratory Use Context

LGD-4033 powder is provided exclusively for in-vitro research and analytical testing. It is a primary reagent for:

• Investigating tissue-selective androgen receptor modulation in cell cultures.
• Studying the molecular pathways of osteoblast activity and muscle protein synthesis.
• Calibration and validation of LC-MS and GC-MS equipment for SARM screening.
• In-vitro toxicity and stability profiling in synthetic biological matrices.

E. Quality Testing

• HPLC Verification: Every batch is rigorously tested to confirm ≥99% chemical purity and the absence of related synthesis precursors.
• Structural Identity: Mass Spectrometry (MS) and Proton NMR verify the presence of the trifluoromethyl and pyrrolidine structural components.
• Batch Consistency: Manufactured under strict laboratory protocols to ensure reproducible results for complex longitudinal studies.
• COA: Comprehensive Certificates of Analysis are available for all institutional research requirements.

F. Shipping Handling

Our LGD-4033 powder is dispatched in professional, moisture-proof, and UV-protected packaging to maintain chemical integrity during transit. We provide reliable, discreet worldwide shipping to support the requirements of international research facilities and commercial laboratories.

G. Compliance Disclaimer (CLEAR PROMINENT)

FOR RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION. This product is a research chemical and is strictly intended for in-vitro laboratory applications and analytical testing. It is not intended for diagnostic or therapeutic use in humans or animals. No medical instructions or dosages are provided. The purchaser is solely responsible for compliance with all local and international laws regarding the acquisition and handling of this substance.